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GraphPad Prism 9——科学绘图软件

Prism 适用于两个平台:GraphPad Prism for Windows 5.02 和 Mac. 5.0b。
Prism 绘图统计分析软件。特色:绘图迅速、页面编排容易、最容易使用的Curve fitting(具有线性及非线性功能)、内建统计功能及统计辅助辅导员、各种2D绘图方式。InStat统计软件,会一步一步的协助您,清楚的分析选项,独特的分析检查条列让您更容易了解结果。
StatMate 统计软件,搭配Prism及InStat. StatMate使用,提供八种统计计算。


GraphPad-Prism 9 已正式发布,新功能介绍 点击查看详情

使用Prism比以往更快地分析,绘制和呈现科学数据!

概述

GraphPad Prism适用于Windows和Mac电脑,它结合了科学绘图,综合曲线拟合(非线性回归),可理解的统计数据和数据组织。
GraphPad Prism最初是为医学院和制药公司的实验生物学家设计的,特别是在药理学和生理学方面。现在,Prism 被各种生物学家以及社会和物理科学家广泛使用。超过110多个国家的20多万科学家依靠Prism来分析,绘制和展示他们的科学数据。它也被本科生和研究生广泛使用。

非线性回归

非线性回归是分析数据的重要工具,但通常比它需要的更难。没有其他程序像Prism那样可以简化曲线拟合。实际上,您通常可以在一个步骤中拟合曲线。只需从常用方程的广泛列表中选择一个方程式(或输入自己的方程式),Prism自动完成剩下的方程式---拟合曲线,将结果显示为表格,在图表上绘制曲线,并插入未知值。
将多个数据集的数据并排放置在有组织的数据表上,Prism可以同时将所有数据集放入其中。 可以将相同的模型分别放入每个数据集,使用全局非线性回归在数据集之间共享参数值,或将不同的模型拟合到不同的数据集中。
Prism还为您提供了许多先进的配件选择。可以将最佳拟合参数的置信区间报告为不对称范围(轮廓似然法),这比通常的对称区间更精确。还可以从标准曲线中自动插入未知值(即分析RIA数据),使用F检验或Akaike的信息准则(AIC)比较两个方程的拟合,绘制残差,识别离群值,差分权重数据点,测试 正常性的残差,等等。

可以理解的统计数据

虽然它不会取代大型统计程序,但Prism可以让您轻松执行实验室和临床研究人员常用的基本统计测试。Prism提供t检验,非参数比较、单、双和三向方差分析,应急表的分析和生存分析。分析选择以清晰的语言呈现,避免了不必要的统计术语。
与其他程序不同,Prism提供可理解的统计帮助。从任何数据分析对话框中按“Learn”按钮,Prism的在线文档将解释分析的原理,以帮助您做出适当的选择。一旦做出选择,Prism就会在有组织,易于理解的表格上展示结果。Prism文档超出了您的预期。其中一半以上用于彻底解释基本统计和非线性曲线拟合,教您如何正确分析数据。

分析清单

完成分析后,Prism独特的分析检查表可帮助确保选择适合您的实验设计的分析,并了解分析背后的假设。

追溯每一个分析

除非能准确记录数据的分析方式,否则这不是真正的科学。对Prism来说这不是问题。您远不会想知道结果如何。即使工作是由其他人完成的,您也可以查看(并更改)所有分析选择,并查看分析顺序(即在曲线拟合之前将X值转换为对数)。同样,可以轻松检查误差条是否代表SD还是SEM(或其他)。

自动化无需编程

Prism项目的所有部分都是相互关联的。这意味着当修复数据输入错误时,Prism会自动更新所有结果,图形和布局。另一个优点是可以立即分析重复实验。在使用来自一个实验的数据完成分析和绘图步骤之后,就不必重复所有这些步骤。Prism提供了几种回收工作的方法---分析和绘制重复实验,无需重复任何繁琐的步骤,无需任何脚本或编程。Prism还为那些想要更复杂的自动化的人提供脚本语言。

自动错误条

如果输入原始数据,Prism可以自动将误差条绘制为SD,SEM,范围,四分位数范围或95%置信区间。
如果您在其他位置计算了误差值,请将它们输入标记(SD或SEM)子列。Prism的分析(即t检验,ANOVA,回归)将考虑SD(或SEM)和样本大小。

完整的工作记录

Prism项目文件不仅包含数据、分析和图形。Prism文件可以是您实验的完整记录。每个文件可以包含任意数量的数据表、信息页面、分析结果、图表和页面布局。
数据表不仅可以包含分析的数据和图形,还可以包含您决定排除的数据,这些数据保留在数据表中(蓝色斜体)。可以突出显示稍后要查看的值。
每个信息页面都可以存储成非结构化注释和结构化信息常量,例如批号、浓度、笔记本页码等。
图形和布局可以用文字、线条、箭头、方框、表格、方程式、图片等装饰。
用颜色编码的浮动笔记对任何页面进行注释,并突出显示(您选择的颜色)要再次查看的页面名称,或者希望其他人查看。
将Prism文件保存在计算机或网络上,或直接保存到基于云的实验室笔记本LabArchives。

准备发布

Prism将从原始数据转移到图形(或布局),准备好演示文稿、海报或出版物。单击即可将完成的图形或布局发送到PowerPoint或Word。当然,复制和粘贴也可以。导出为TIFF、EPS、JPG或PDF(及更多)格式,以及满足科学期刊要求所需的所有选项。

Prism最新版新功能

Prism允许您进行更多种类的统计分析,制作更多种的图表,并更灵活地组织数据。但是Prism仍然是Prism!您可以切换到几乎没有学习曲线的Prism最新版,使用Prism最新版的试用而无需删除早期版本。

以下是一些亮点

热点图
三因素方差分析
FDR方法进行多重比较
非线性回归更精确(不对称,似然)的置信区间
标签子列
颜色代码表名称和表格中的选定单元格
半透明的颜色,所以您可以看到重叠
输入日期(或已过去次)作为X值

系统需求

Gaphpad Prism适用于Windows和Mac系统。

GraphPad Prism is a powerful combination of biostatistics, curve fitting (nonlinear regression) and scientific graphing in one comprehensive program. Easily organize, analyze and graph repeated experiments; pick appropriate statistical tests and interpret the results. Windows or Macintosh.
GraphPad Prism is a powerful combination of basic biostatistics, curve fitting and scientific graphing in one comprehensive program. Because it easily organizes, analyzes and graphs repeated experiments; picks appropriate statistical tests; and interprets the results, Prism is ideally suited to data plotting and analysis applications in the life sciences.

Prism Features
GraphPad Prism V 6 is available for both Windows and Macintosh. The two versions are very similar. You can open files created on one platform on the other platform with no special conversion. The program has almost identical interfaces on the two platforms, so you can switch back and forth with virtually no learning curve. The main difference is that the Mac version does not support Object Linking and Embedding (OLE).

Curve fitting features:
Equations

Marquardt-Levenberg nonlinear regression.
Fit data to a built-in classic equation, choose from an equation library, or enter your own.
Built-in equations include kinetic equations (exponential decay, growth, association), equilibrium mass action equations (binding isotherm, sigmoidal dose-response, competitive binding including 2 site), polynomial up to 4th order, Gaussian distribution, power series and sine.
Enter multiple-line user-defined equations, including If-Then clauses. Define different equations for different data sets (columns).
Generate a family of theoretical curves.
Create equation libraries to distribute to others.
Fitting options

Automatic initial values.
Fit to replicate Y values or mean Y.
Fix any parameter to a constant value or constrain to a range of values.
Weight by 1/Y, 1/Y2, 1/X, 1/X2, 1/SD2 distances.
Fit data to two equations and compare fits with an F test. Automatically graph the best fit.
Global fitting. Fit several data sets at once, sharing selected parameters between the data sets.
Compare two curves by comparing the sum of squares when selected parameters are shared between the data sets with the individual sum of squares.
Compare models (and data sets) using the extra sum-of-squares F test or Akaike’s Information Criterion (AIC).
Output options

Comprehensive results include value of parameters with SEM and 95% CI, df, R2, sum of squares, and residuals (Sy.x).
Perform a runs test for goodness-of-fit.
Calculate (and graph) residuals.
Use any curve as a standard curve. Calculate Y from X, or X from Y.
Calculate dose-ratios for Schild plot.
Compute Ki from IC50 (method of Cheng and Prusoff).
Table of XY coordinates defining the curve.
Customizable summary table of best-fit values.
Data management features:
Data entry

Enter Y data as raw replicates or mean, SD/SEM and N.
Automatic updating of analyses and graphs as data change.
Enter up to 104 related data sets on one table to be analyzed and plotted together. Up to 52 replicates and any number of points per data set
Accurately accounts for missing values.
Exclude specified points from analyses and graphs (they show on the table in blue italics, but are ignored by the analyses and graphs).
Transfer data to and from Excel and other applications with the clipboard, or import and export text (ASCII) files.
Data Importing

Import text files and retain the link. Double click on the Prism data to edit the text file.
Choose rows and columns to import.
Filter row. Choose to start importing after a condition is met, and to stop importing when another condition is met.
Filter columns. Choose a range of columns to import.
Decimate. Skip several rows after every row that is imported.
Unstack indexed data.
Transpose rows and columns.
Import free-form notes and structured info constants along with data.
Use Excel data in Prism

Copy and paste data and results between Prism and Excel.
Paste a link from Excel into Prism. Double-click on the Prism data to return to Excel (Windows only).
Embed an entire spreadsheet file within a Prism file (Windows only).
Import Excel files directly (Windows only).
Data preprocessing

Normalize, sort or transpose data.
Subtract (or divide by) a baseline or compute relative changes.
Consolidate related data sets by calculating means or totals.
Transform data with a full range of mathematical functions, including user-defined transforms.
Smooth curves, or convert to their derivative or integral.
Info tables

Use Info tables to record experimental details such as experiment or lot number, or enter numerical constants (such as concentration) that can be used in analyses.
Link each info table, with associated free-form notes, to particular data table or to the entire project.
Enter the info constants manually or import from text files along with your data.
Use values entered on info sheets as constants in nonlinear regression or transforms, or as titles and text objects.
Efficiently analyze repeat experiments

Instantly analyze and graph a new data table exactly as you have already analyzed and graphed another data table in the project.
Save analysis and graphing steps in templates and methods files, to be used in new projects.
Run Prism scripts to automate importing, analyzing and graphing a large series of experiments.
Statistics features:
Linear regression and correlation

Calculate slope and intercept with confidence intervals
Force the regression line through a specified point
Fit to replicate Y values or mean Y
Test for departure from linearity with a runs test
Calculate and graph residuals
Compare slopes and intercepts of two or more regression lines
Determine new points along the standard curve
Pearson or Spearman (nonparametric) correlation
Table of XY coordinates
Column statistics

Calculate min, max, quartiles, mean, SD, SEM, CI, CV, Geometric mean with Confidence Intervals
Specify desired level of confidence
Frequency distributions (bin to histogram), including cumulative histograms.
Kolgoromov-Smirnov normality test
One sample t test or Wilcoxon test to compare the column mean (or median) with a theoretical value
Skewness and Kurtosis
Statistical comparisons

Kaplan-Meier survival analysis. Compare curves with the log-rank test (including test for trend)
Paired or unpaired t tests
Mann-Whitney or Wilcoxon tests
Ordinary or repeated measures one-way ANOVA with Tukey, Newman-Keuls, Dunnett or Bonferroni post tests, or the post-test for trend
Kruskal-Wallis or Friedman nonparametric one-way ANOVA with Dunn’s post test
Fisher’s exact test or the chi-square test. Calculate the relative risk and odds ratio with confidence intervals
Two-way ANOVA, even with missing values with some post tests
Repeated measures two-way ANOVA with some post tests
Clinical (diagnostic) lab statistics

Bland-Altman plots
Receiver operator characteristic (ROC) curves
Deming regression (type ll linear regression)
Graphing features:
Axes and ticks

Linear, log10, or log2 scale, ascending or descending numbering.
Segment axes with up to two breaks (gaps) per axis.
Select orientation of tick marks and adjust major and minor intervals. Choose tick length.
Label ticks using decimal, scientific, 10^X, or notation.
Place custom ticks and labels anywhere on an axis.
Offset X and Y axes.
Add a right-hand Y axis.
Choose number of decimal points for axis numbering.
Precede axis numbers with a prefix (i.e. ’$’) and follow with a suffix (i.e. ’%’)
Numbering under X axis can be at any angle.
Move numbering and axis title closer to, or further from, the axis.
Symbols, lines, and graph types

XY graphs, bar graphs (vertical or horizontal), box-and-whisker plots, and scatter plots.
Plot hundreds data sets on a single graph. Add or remove data sets.
Create graphs with no frame, a plain frame, a frame with ticks, or a frame with a grid.
Adjust size and shape of graph by specifying dimensions or dragging with the mouse.
14 different symbols in 9 sizes.
5 line patterns (dotted, dashed, etc.) in 7 line thicknesses and 16 colors.
Connect points with a line, staircase, or spline curve.
Start point-to-point lines at the origin or the first data point.
Change origin position: lower left, automatically selected, or custom.
Built-in drawing tools--lines, arrows, boxes, circles, ovals, and arcs.
Error bars

Automatic calculation of error bars from replicate values.
Plot mean and SD, mean and SEM, mean and 95% CI, mean and range, median and range, or median and interquartile range.
Error bars can be above or below the point, or both, and with caps or without.
Specify error bar thickness.
Option to suppress error bars.
Text and legends

Automatic legends that are customizable.
Easily access Greek letters, mathematical symbols, or international characters.
Rotate text any angle.
Add underlining, bold, super and subscripts, or change point size easily from the tool bar.
Move graph and axis titles without losing centering.
Page layout features:
Graph arrangement

Built-in page layout templates for automatic arrangement of multiple graphs.
Move, resize, delete or add graphs.
Include data, results tables and graphs on one page.
Import images as .TIF, .PCX, .BMP, .JPG .GIF, .WMF (Windows) or PICT (Mac) files.
Create portrait and landscape pages in one file.
Tools to equalize the size, and align axes, of several graphs.
6 levels of zoom.
Layouts will automatically update when you edit a graph or data plotted on the graph – even if the graph comes from a different Prism file.
Page enhancements

Draw lines, arrows, boxes, circles, ovals and arcs.
Add text, including Greek letters and super- or subscripts.
Align objects (left, right, center, top, bottom) or align graphs by X or Y axes.
Send to back. Bring to front.
Duplicate objects or groups of objects.
Group and ungroup objects.
Use rulers, snap to guidelines, superimpose grid.
Choose any color for any data set or object, and define your own palette of custom colors.
Embed OLE objects, such as equations and WordArt. (Windows only)
Embed data and results tables on graphs or page layouts

Paste any portion of a data, results or info table onto a graph or layout.
Customize the table with a border, grid lines, or titles.
Create text tables as well as numerical tables.
Place any number of tables on one graph or layout page.
Prism automatically updates tables when you edit the data.
Publication quality output

Print in color or black and white.
Copy and paste into Word or PowerPoint.
One-click copy and paste into a new slide in PowerPoint (Windows only).
Embed or link a Prism graph into PowerPoint or Word using OLE (Windows only).
Export as a wmf (Windows) or pict (Mac) file.
Export as a bitmap in png, bmp, jpg, or tif format at up to 1200 dots per inch.
Choose RGB or CMYK colors. Choose whether to include background color in exported file.
Email an entire file, or just one page, right from Prism (Windows only).
Post one graph or layout, or all graphs or layouts, to a web server.

What makes Prism truly unique, however, is not just what it does, but how it does it! Designed for laboratory and clinical researchers, Prism doesn’t expect you to be a statistician. It guides you through the analysis process – giving you as much help as you need – and tracks and organizes like no other program available. You can concentrate on your data, not on figuring out how to use the program.


Need to see for yourself? Our free demo version lets you try Prism with your own data. Download the fully functional Prism demo and use it for 30 days for free. It’s the best way to see if Prism is the right choice for you.

We guarantee your satisfaction. If Prism does not meet or exceed your expectations, return it within 90 days of purchase for a fast, courteous refund.

Publishing graphs with Prism

We designed Prism to produce quality graphs. There are a variety of options that are available for publishing your graphs.

Copy/Paste. With many applications you can simply Copy your Prism graph and Paste it into another application. With Prism Windows, you’ll be pasting a Prism object that includes all data and results. Double-click on the pasted graph to edit it with Prism.

Export your graphs from Prism in the format that best suits your needs. Choose from:

TIF – High resolution tif files at up to 1200 DPI in CMYK or RGB for publcation
JPEG – web format
WMF – Windows Metafile, Windows only
PICT – Macintosh only
PNG – web format
BMP – bit map format
PCX – bit map format
Post to web sever. With one click you can post your graphs to the web. Simply email the link to your collegues for them to view.

Powerpoint and Word – Prism is designed to work hand-in-hand with Office applications, seamlessly exchanging data and graphics with Word and PowerPoint

Well-organized so you can organize well!

With Prism, you can store all parts of an experiment (several data tables linked to results, graphs, page layouts and notes) in one organized file. You can decide how much information to include in one project file. You can place all your data tables into one file, along with linked results and graphs. Or you can also separate your work into lots of files. Prism lets you choose how to organize your work.

Record experimental details

Because science requires rigorous record keeping, Prism lets you enter unstructured notes and structured data (notebook number, experimenter, lot number, concentration, etc.) onto Info sheets. It’s an ideal way to keep each part of your experiment organized and on target. Each info sheet can be linked to a particular data table or be general for the entire project. You can use info constants as constants in transforms, as constraints in nonlinear regression, and as graph titles and legends.

Automatic linking

Save time and help eliminate errors with automatic linking.

If you edit data, Prism automatically recomputes linked analyses and replots linked graphs.
If you exclude a ’bad’ data point, it will remain on the data table (in blue italics) but be omitted from analyses and graphs, which are automatically updated.
If you change analysis choices, the results are recomputed (along with any chained analyses) and linked graphs updated.
If you edit info constants, Prism automatically recomputes linked analyses and recreates graphs where those info constants are used.
If you edit a graph, Prism automatically redraws linked page layouts, even if the graph is included on a layout in a different file.
Summarize your experiments on one page

Prism makes it very easy to create page layouts containing multiple graphs, and provides tools to equalize the graph size and to align axes. These graphs can all come from one project, or each can come from a different project. Either way, everything is fully linked and the page layout will be updated when you edit your data or change the analysis choices. You may add drawings, text, and imported pictures to the layout, as well as data and results tables. This lets you turn a page layout into a complete one-page summary of your experiments for presentations, papers, or your lab notebook.

Chain analyses

If you chain analyses (for example, first transform the data, then do nonlinear regression, then do a normality test on the residuals), you can view them in a nested view (data plus results) to clearly document the order of the analyses.

Automatic error bars

Simply enter your replicate values and view the linked graph. Prism automatically creates a graph with error bars. The calculations are entirely automatic, and you may display your error bars as the SD, SEM, 95% CI, mean and range, median and range, or median and quartiles.

Simultaneous analysis of related data sets

Experiments typically compare several experimental conditions. With Prism, one command analyzes and graphs all the related data sets in your data table. You don’t need to repeat commands for each experimental condition.

Instant analysis of data from repeat experiments

You rarely perform an experiment just once; you repeat it to verify the results. Prism lets you analyze and graph data from a repeat experiment instantly. Click once to duplicate the data table, along with linked analyses and graphs. Then enter the new data, and instantly view linked results and graphs. You don’t have to retype commands and don’t need to create complicated batch files or macros. Save even more time by saving your work as a template. Every time you repeat an experiment, simply open the template, enter the data and info constants, and you are done.